Please note: Metoclopramide and domperidone are not licensed for the treatment of gut motility problems including managment of oesophageal reflux, gastroparesis and in some patients with non-ulcer dyspepsia. Benefit no longer outweighs risk. Please see the link to safety information below.
Due to the risk of neurological adverse effects metoclopramide should only be prescribed for short term use (up to 5 days) and the maximum dose in 24 hours is 30mg (or 0.5mg/kg body weight). For more information see Drug Safety Update, August 2013
Motility stimulants were used in the management of oesophageal reflux, gastroparesis, nausea and in some patients with non-ulcer dyspepsia.
Erythromycin suspension 125mg three times a day before meals is sometimes used to stimulate gastric motility (unlicensed indication). Please see NICE evidence review for an unlicensed or off-label medicine. ESUOM13 Gastroparesis in adults - oral erythromycin, June 2013.