Drug Safety Update
Drugs and driving: blood concentration limits to be set for certain controlled drugs in a new legal offence, July 2014. See also the drugs and driving: the law government webpage for more details
NICE Guidance (see also drug-specific links below)
Melatonin MR tablets are included in the formulary for "off label" use in the treatment of sleep disorders in children with conditions such as visual impairment, cerebal palsy, ADHD and learning difficulties. These tablets may be crushed and mixed with water, milk, yoghurt or fruit juice for administration; this gives an immediate release profile.
There is currently a review underway to consider update to the formulary listing and guidance for melatonin products given the availability of new licensed products.
MTW only: For the purposes of single dose prescriptions of melatonin for sleep EEG in children, melatonin tablets (Adaflex) may be dispensed.
NPPG Position Statement
This formulation is unlicensed and is not for routine use - it may be prescribed in exceptional circumstances only e.g. if the 2mg MR tablets are unavailable following consultation with relevant medicines management leads.