Migraine
Drug Safety Update
 December 2014: Treating paracetamol overdose with intravenous acetylcysteine: new guidance
 January 2017: Intravenous N-acetylcysteine (NAC) for paracetamol overdose: reminder of authorised dose regimen; possible need for continued treatment with NAC.Â
NICE Guidance (see also drug specific links below)
 CG150 Headaches in over 12s: diagnosis and management, updated November 2015
 TA260 Botulinium toxin type A for the prevention of headaches in adults with chronic migraine, June 2012
Treatment of a migraine attack should be guided by response to previous treatment and the severity of the attacks. A simple analgesic such as aspirin, paracetamol (preferably in a soluble or dispersible form) or ibuprofen is often effective; concomitant antiemetic treatment may be required. If treatment with an analgesic is inadequate, an attack may be treated with a specific antimigraine compound such as a 5HT1-receptor agonist (‘triptan’).
Other drugs used in the treatment of migraine particularly prophylaxis against an attack include propranolol, topiramate, gabapentin and botulinum toxin.
Kent & Medway CCG guidance on the use of Botulinum toxin type A and calcitonin gene-related peptide inhibitors for preventing migraine in adults, March 2021
| Pack | Price |
|---|---|
| 100 tablet | £2.17 |
| 100 tablet (10 x 10 tablets) | £2.20 |
| 1000 tablet | |
| 16 tablet (2 x 8 tablets) | £0.36 |
| 30 tablet (3 x 10 tablets) | £0.82 |
| 32 tablet | £0.49 |
| Pack | Price |
|---|---|
| 100 capsule (10 x 10 capsules) | £4.63 |
| 16 capsule | £0.48 |
| 32 capsule | £1.48 |
| Pack | Price |
|---|---|
| 100 tablet (10 x 10 tablets) | £8.21 |
| 24 tablet (4 x 6 tablets) | £10.64 |
| 60 tablet | £8.80 |
| Pack | Price |
|---|---|
| 100 ml | £1.74 |
| 500 ml |
| Pack | Price |
|---|---|
| 100 ml | £1.63 |
| 1000 ml | £16.30 |
| 200 ml | £3.26 |
| Pack | Price |
|---|---|
| 100 ml | £2.77 |
| 500 ml | £13.85 |
| Pack | Price |
|---|---|
| 100 ml | £1.80 |
| 1000 ml | £12.60 |
| 200 ml | £2.85 |
| 500 ml | £7.81 |
| Pack | Price |
|---|---|
| 10 suppository | £11.95 |
| Pack | Price |
|---|---|
| 10 suppository | £12.39 |
| Pack | Price |
|---|---|
| 10 suppository | £22.01 |
| Pack | Price |
|---|---|
| 10 suppository | £41.27 |
| Pack | Price |
|---|---|
| 10 vial |
| Pack | Price |
|---|---|
| 32 tablet (4 x 8 tablets) | £1.28 |
| 100 tablet |
| Pack | Price |
|---|---|
| 10 suppository | £23.73 |
| Pack | Price |
|---|---|
| 10 suppository | £45.60 |
| Pack | Price |
|---|---|
| 24 tablet | £0.80 |
| 48 tablet (4 x 12 tablets) | £1.47 |
| 84 tablet | £3.82 |
| Pack | Price |
|---|---|
| 24 tablet | £1.39 |
| 48 tablet (4 x 12 tablets) | £2.56 |
| 84 tablet (7 x 12 tablets) | £4.10 |
| Pack | Price |
|---|---|
| 100 ml | £2.39 |
| 150 ml | £3.42 |
| 500 ml | £10.28 |
| Pack | Price |
|---|---|
| 3 tablet | |
| 6 tablet | £26.73 |
| Pack | Price |
|---|---|
| 12 tablet | |
| 2 tablet | |
| 3 tablet | £3.07 |
| 6 tablet |
| Pack | Price |
|---|---|
| 12 tablet | |
| 2 tablet | |
| 4 tablet | |
| 6 tablet | £1.38 |
| Pack | Price |
|---|---|
| 12 tablet | |
| 2 tablet | |
| 4 tablet | |
| 6 tablet | £1.55 |
| Pack | Price |
|---|---|
| 2 unit dose | £14.16 |
| Pack | Price |
|---|---|
| 2 pre-filled disposable injection | £50.96 |
| Pack | Price |
|---|---|
| 12 tablet (2 x 6 tablets) | £4.53 |
| 6 tablet | £2.27 |
| Pack | Price |
|---|---|
| 6 tablet | £43.20 |
| Pack | Price |
|---|---|
| 6 tablet | £6.30 |
| Pack | Price |
|---|---|
| 6 tablet | £12.00 |
| Pack | Price |
|---|---|
| 6 unit dose | £36.50 |
| Pack | Price |
|---|---|
| 1 pre-filled disposable injection | £386.50 |
| Pack | Price |
|---|---|
| 1 pre-filled disposable injection | £450.00 |
| Pack | Price |
|---|---|
| 1 pre-filled disposable injection | £450.00 |
| Pack | Price |
|---|---|
| 1 pre-filled disposable injection | £450.00 |