Migraine
Drug Safety Update
June 2023: Non-steroidal anti-inflammatory drugs (NSAIDs): potential risks following prolonged use after 20 weeks of pregnancy
January 2017: Intravenous N-acetylcysteine (NAC) for paracetamol overdose: reminder of authorised dose regimen; possible need for continued treatment with NAC.
December 2014: Treating paracetamol overdose with intravenous acetylcysteine: new guidance
NICE Guidance (see also drug specific links below)
CG150 Headaches in over 12s: diagnosis and management, updated November 2015
TA260 Botulinium toxin type A for the prevention of headaches in adults with chronic migraine, June 2012
Treatment of a migraine attack should be guided by response to previous treatment and the severity of the attacks. A simple analgesic such as aspirin, paracetamol (preferably in a soluble or dispersible form) or ibuprofen is often effective; concomitant antiemetic treatment may be required. If treatment with an analgesic is inadequate, an attack may be treated with a specific antimigraine compound such as a 5HT1-receptor agonist (‘triptan’).
Other drugs used in the treatment of migraine particularly prophylaxis against an attack include propranolol, topiramate, gabapentin and botulinum toxin.
See here for K&M CCG Management of Adults with Headaches and Migraines in Primary Care
| Pack | Price |
|---|---|
| 100 tablet | £3.09 |
| 100 tablet (10 x 10 tablets) | £2.08 |
| 1000 tablet | £34.76 |
| 16 tablet (2 x 8 tablets) | £0.50 |
| 30 tablet (3 x 10 tablets) | £0.80 |
| 32 tablet | £0.67 |
| Pack | Price |
|---|---|
| 100 capsule (10 x 10 capsules) | £3.09 |
| 16 capsule | £0.60 |
| 32 capsule | £0.99 |
| Pack | Price |
|---|---|
| 100 tablet (10 x 10 tablets) | £25.52 |
| 24 tablet (4 x 6 tablets) | £10.64 |
| 60 tablet |
| Pack | Price |
|---|---|
| 100 ml | £6.28 |
| 500 ml |
| Pack | Price |
|---|---|
| 100 ml | £2.71 |
| 1000 ml | |
| 200 ml | £6.02 |
| Pack | Price |
|---|---|
| 100 ml | £7.04 |
| 500 ml | £34.87 |
| Pack | Price |
|---|---|
| 100 ml | £3.30 |
| 1000 ml | £47.30 |
| 200 ml | £13.20 |
| 500 ml | £18.70 |
| Pack | Price |
|---|---|
| 10 suppository | £11.95 |
| Pack | Price |
|---|---|
| 10 suppository | £23.01 |
| Pack | Price |
|---|---|
| 10 suppository | £62.31 |
| Pack | Price |
|---|---|
| 10 suppository | £41.27 |
| Pack | Price |
|---|---|
| 10 vial |
| Pack | Price |
|---|---|
| 32 tablet (4 x 8 tablets) | £0.93 |
| 100 tablet |
| Pack | Price |
|---|---|
| 10 suppository |
| Pack | Price |
|---|---|
| 10 suppository |
| Pack | Price |
|---|---|
| 24 tablet | £0.66 |
| 48 tablet (4 x 12 tablets) | £2.72 |
| 84 tablet | £2.35 |
| Pack | Price |
|---|---|
| 24 tablet | £2.57 |
| 48 tablet (4 x 12 tablets) | £1.46 |
| 84 tablet (7 x 12 tablets) | £2.59 |
| Pack | Price |
|---|---|
| 100 ml | £1.52 |
| 150 ml | £4.18 |
| 500 ml | £17.16 |
| Pack | Price |
|---|---|
| 3 tablet | |
| 6 tablet | £28.26 |
| Pack | Price |
|---|---|
| 12 tablet | |
| 2 tablet | |
| 3 tablet | £9.65 |
| 6 tablet |
| Pack | Price |
|---|---|
| 12 tablet | |
| 2 tablet | |
| 4 tablet | |
| 6 tablet | £0.88 |
| Pack | Price |
|---|---|
| 12 tablet | |
| 2 tablet | |
| 4 tablet | |
| 6 tablet | £1.17 |
| Pack | Price |
|---|---|
| 2 unit dose | £14.16 |
| Pack | Price |
|---|---|
| 2 pre-filled disposable injection | £50.96 |
| Pack | Price |
|---|---|
| 12 tablet (2 x 6 tablets) | £34.52 |
| 6 tablet | £24.00 |
| Pack | Price |
|---|---|
| 6 tablet | £71.17 |
| Pack | Price |
|---|---|
| 6 tablet | £10.53 |
| Pack | Price |
|---|---|
| 6 tablet | £14.13 |
| Pack | Price |
|---|---|
| 6 unit dose | £36.50 |
| Pack | Price |
|---|---|
| 1 pre-filled disposable injection | £386.50 |
| Pack | Price |
|---|---|
| 1 pre-filled disposable injection | £450.00 |
| Pack | Price |
|---|---|
| 1 pre-filled disposable injection | £450.00 |
| Pack | Price |
|---|---|
| 1 pre-filled disposable injection | £450.00 |
| Pack | Price |
|---|---|
| 28 tablet (4 x 7 tablets) | £182.16 |
Reduce dose to 10 mg once daily with concurrent use of potent CYP3A4 inhibitors, OATP inhibitors, or telmisartan.
| Pack | Price |
|---|---|
| 28 tablet (4 x 7 tablets) | £182.16 |
In accordance with NICE TA919
See here for K&M Rimegepant Prescribing Guideline for Primary Care
| Pack | Price |
|---|---|
| 2 tablet | £25.80 |
| 8 tablet | £103.20 |
In accordance with NICE TA906
| Pack | Price |
|---|---|
| 2 tablet | £25.80 |
| 8 tablet | £103.20 |
