Drug Safety Update
December 2014: Treating paracetamol overdose with intravenous acetylcysteine: new guidance
January 2017: Intravenous N-acetylcysteine (NAC) for paracetamol overdose: reminder of authorised dose regimen; possible need for continued treatment with NAC.
NICE Guidance (see also drug specific links below)
CG150 Headaches in over 12s: diagnosis and management, updated November 2015
TA260 Botulinium toxin type A for the prevention of headaches in adults with chronic migraine, June 2012
Treatment of a migraine attack should be guided by response to previous treatment and the severity of the attacks. A simple analgesic such as aspirin, paracetamol (preferably in a soluble or dispersible form) or ibuprofen is often effective; concomitant antiemetic treatment may be required. If treatment with an analgesic is inadequate, an attack may be treated with a specific antimigraine compound such as a 5HT1-receptor agonist (‘triptan’).
Other drugs used in the treatment of migraine particularly prophylaxis against an attack include propranolol, topiramate, gabapentin and botulinum toxin.
Kent & Medway CCG guidance on the use of Botulinum toxin type A and calcitonin gene-related peptide inhibitors for preventing migraine in adults, March 2021