MTW NHS Trust West Kent CCG

Drug Status Key

  • Preferred
  • Second Line
  • Third Line
  • Specialist Initiation
  • Hospital Only
  • Not Approved for Formulary

Antiemetics and Antinauseants

Drug Safety Update

 August 2012: Ondansetron (Zofran) important new intravenous dose restrictions for high doses used in the management of chemotherapy induced nausea and vomiting

 August 2013: Ondansetron for intravenous use posology in patients aged 65 years and older - new advice on dilution and administration when being used for the management of chemotherapy induced nausea and vomiting

 August 2013: Metoclopramide - risk of neurological side effects

 May 2014: Domperidone - risk of cardiac side effects

 December 2019: Domperidone for nausea and vomiting: lack of efficacy in children; reminder of contraindications in adults and adolescents

 January 2020: Ondansetron: small increased risk of oral clefts following use in the first 12 weeks of pregnancy

July 2023: Hyoscine hydrobromide patches (Scopoderm 1.5mg Patch or Scopoderm TTS Patch): risk of anticholinergic side effects, including hyperthermia

First-line for PONV

Pack Price
10 tablet £9.50
30 tablet £5.01
Pack Price
10 tablet £6.37
Pack Price
10 tablet £38.47
Pack Price
10 tablet £85.42
Pack Price
50 ml £35.27
Pack Price
5 ampoule £20.00
Pack Price
5 ampoule £28.37

Useful for the treatment of vertigo

Pack Price
28 tablet (2 x 14 tablets) £1.74
84 tablet (6 x 14 tablets) £5.24

Buccastem can be purchased OTC for nausea & vomiting in previously diagnosed migraine

Pack Price
8 tablet £4.01
Pack Price
10 ampoule £5.23

Effective in treating nausea and vomiting resulting from many underlying causes. Use second line for PONV.

Pack Price
100 tablet (10 x 10 tablets) £4.39
Pack Price
5 ampoule £10.66

Licensed for motion sickness also used off licence for hypersalivation

Releases 1mg hyoscine over 72hours

Pack Price
2 patch £12.87
Pack Price
100 tablet (10 x 10 tablets) £2.07
30 tablet (3 x 10 tablets) £0.62
Pack Price
200 ml £49.32

Used in palliative care

Pack Price
84 tablet (3 x 28 tablets) £20.26
Pack Price
10 ampoule £20.13

Used for nausea & vomiting associated with cancer chemotherapy or palliative care.

Dexamethasone injection is usually prescribed in terms of dexamethasone base - see IV guide for more details.

Pack Price
100 tablet £8.93
50 tablet £3.37
Pack Price
10 ampoule £21.37
Pack Price
10 vial £19.99