Antiemetics and Antinauseants
Drug Safety Update
August 2012: Ondansetron (Zofran) important new intravenous dose restrictions for high doses used in the management of chemotherapy induced nausea and vomiting
August 2013: Ondansetron for intravenous use posology in patients aged 65 years and older - new advice on dilution and administration when being used for the management of chemotherapy induced nausea and vomiting
August 2013: Metoclopramide - risk of neurological side effects
May 2014: Domperidone - risk of cardiac side effects
December 2019: Domperidone for nausea and vomiting: lack of efficacy in children; reminder of contraindications in adults and adolescents
January 2020: Ondansetron: small increased risk of oral clefts following use in the first 12 weeks of pregnancy
July 2023: Hyoscine hydrobromide patches (Scopoderm 1.5mg Patch or Scopoderm TTS Patch): risk of anticholinergic side effects, including hyperthermia
First-line for PONV
| Pack | Price |
|---|---|
| 10 tablet | £9.50 |
| 30 tablet | £4.23 |
| Pack | Price |
|---|---|
| 10 tablet | £1.24 |
| Pack | Price |
|---|---|
| 10 tablet | £43.48 |
| Pack | Price |
|---|---|
| 10 tablet | £85.43 |
| Pack | Price |
|---|---|
| 50 ml | £38.37 |
| Pack | Price |
|---|---|
| 5 ampoule | £20.00 |
| Pack | Price |
|---|---|
| 5 ampoule | £28.37 |
| Pack | Price |
|---|---|
| 28 tablet (2 x 14 tablets) | £0.92 |
| Pack | Price |
|---|---|
| 150 ml | £19.79 |
| Pack | Price |
|---|---|
| 10 ampoule | £4.84 |
Useful for the treatment of vertigo
| Pack | Price |
|---|---|
| 28 tablet (2 x 14 tablets) | £3.22 |
| 84 tablet (6 x 14 tablets) | £7.88 |
Buccastem can be purchased OTC for nausea & vomiting in previously diagnosed migraine
| Pack | Price |
|---|---|
| 8 tablet | £4.01 |
| Pack | Price |
|---|---|
| 10 ampoule | £5.23 |
Effective in treating nausea and vomiting resulting from many underlying causes. Use second line for PONV.
| Pack | Price |
|---|---|
| 100 tablet (10 x 10 tablets) | £3.50 |
| Pack | Price |
|---|---|
| 5 ampoule | £12.25 |
Licensed for motion sickness also used off licence for hypersalivation
Releases 1mg hyoscine over 72hours
| Pack | Price |
|---|---|
| 2 patch | £12.87 |
| Pack | Price |
|---|---|
| 100 tablet (10 x 10 tablets) | £2.50 |
| 30 tablet (3 x 10 tablets) | £0.75 |
| Pack | Price |
|---|---|
| 200 ml | £52.50 |
Used in palliative care
| Pack | Price |
|---|---|
| 84 tablet (3 x 28 tablets) | £20.26 |
| Pack | Price |
|---|---|
| 10 ampoule | £20.13 |
Used for nausea & vomiting associated with cancer chemotherapy or palliative care.
Dexamethasone injection is usually prescribed in terms of dexamethasone base - see IV guide for more details.
| Pack | Price |
|---|---|
| 100 tablet | £8.93 |
| 50 tablet | £3.43 |
| Pack | Price |
|---|---|
| 10 ampoule | £23.99 |
| Pack | Price |
|---|---|
| 10 vial | £19.99 |
| Pack | Price |
|---|---|
| 10 ampoule | £47.21 |
| Pack | Price |
|---|---|
| 10 ampoule | £139.88 |