Drug Safety Updates
April 2012 : Prolonged use of proton pump inhibitors (PPIs) has been associated with hypomagnesaemia - consider checking magnesium levels before starting treatment and repeat measurements periodically during treatment.
April 2012: Long-term use of PPIs has also been linked to fracture.
September 2015: Proton pump inhibitors are associated with infrequent cases of subacute cutaneous lupus erythematosus.
CG 184 Gastro-oesophageal reflux disease and dyspepsia in adults: investigation and management, September 2014
CG141 Acute upper gastrointestinal bleeding in over 16s: management, August 2016
GORD patients with simple reflux should be encouraged to make healthy lifestyle changes eg weight loss, avoid large fatty meals and raise the head of the bed at night. Patients with GORD should be given full dose PPI for 2 months . If symptoms recur and in complicated reflux long term maintenance should be considered.
PPIs should be prescribed for appropriate indications at the lowest effective dose for the shortest period; the need for long-term treatment should be reviewed periodically.
Intravenous omeprazole is used for patients with confirmed upper GI bleeding and those with endoscopic evidence of recurrent haemorrhage. PPIs should not be used prior to diagnosis by endoscopy in patients with upper GI bleeding.
OTC pack sizes available may be different to the pack sizes listed here.