It is recommended that patients receiving aminosalicylates should be advised to report any unexplained bleeding, bruising, purpura, sore throat, fever, or malaise that occurs during treatment. A blood count should be performed and the drug stopped immediately if there is suspicion of a blood dyscrasia.
There is no evidence to show that any one oral preparation of mesalazine is more effective than another however, the delivery characteristics of oral mesalazine preparations may vary. If it is necessary to switch a patient to a different brand of mesalazine, the patient should be advised to report any changes in symptoms.