MTW NHS Trust West Kent CCG

Drug Status Key

  • Preferred
  • Second Line
  • Third Line
  • Specialist Initiation
  • Hospital Only
  • Not Approved for Formulary

Paracetamol toxicity

Drug Safety Update

January 2017: Intravenous N-acetylcysteine (NAC) for paracetamol overdose: reminder of authorised dose regimen; possible need for continued treatment with NAC

July 2016: N-acetylcysteine: risk of false-low biochemistry test results due to interference with Siemens assays

December 2014: Treating paracetamol overdose with intravenous acetylcysteine: new guidance

Paracetamol toxicity has traditionally been treated by a 21-hour infusion (3 separate infusions) of N’Acetylcysteine (NAC). Another treatment regime for the treatment of paracetamol toxicity known as the Scottish and Newcastle Acetylcysteine Protocol (SNAP) is also available and only requires a 12-hour infusion (2 separate infusions).

Both regimes for adults and children can be found on the Toxbase website and the Injectable Medicines Guide (Medusa).