Antidotes and chelators
Idarucizumab binds specifically to dabigatran and its metabolites so reversing the anticoagulant effect
Protamine sulfate is used to treat heparin and LMWH overdose
Treatment of known or strongly suspected life-threatening digoxin toxicity associated with ventricular arrhythmias or bradycardia unresponsive to atropine. Used when measures beyond the withdrawal of digoxin and correction of any electrolyte abnormalities are considered necessary.
Andexanet alfa is recommended as an option for reversing anticoagulation from rivaroxaban and apixaban in adults with life-threatening or uncontrolled bleeding if the bleed is in the GI tract