Drug Safety Update
January 2014: Prasugrel increased risk of bleeding advice on loading dose
NICE Guidance (also see drug-specific links below)
TA52: Guidance on the use of drugs for early thrombolysis in the treatment of acute MI, Oct 2002
TA47: Guidance on the use of glycoprotein IIb/IIIa inhibitors in the treatment of ACS, updated March 2010
NG128: Stroke and transient ischaemic attack in over 16s: diagnosis and initial management, May 2019
Aspirin and clopidogrel are also used in the management of patients with acute coronary syndromes. See NICE guidance and section Antiplatelet drugs.
MTW Massive PE with thrombolysis protocol (update due 2020)
MTW use of in-hospital thrombolysis (update due 2020)
Alteplase is also approved for intrapleural use at MTW by a respiratory consultant for the management of pleural infection in adults (unlicensed indication and route) only when surgery/transfer to tertiary care is not an option. It is to be requested from pharmacy on an individual patient basis only for this indication.