Lipid regulating drugs
Drug Safety Update
 January 2008: Statin interactions and updated advice for atorvastatin
 February 2008: Statins - additional side effects including depression, sleep disturbance, memory loss, interstitial lung disease, and sexual dysfunction
 May 2010: Simvastatin increased risk of myopathy at high doses (80mg)
  December 2010: Fibrates first line treatment not recommended except for those with severe hypertriglyceridaemia
  January 2012: Statins risk of hyperglycaemia and diabetes
  August 2012: and October 2012 Updated advice on simvastatin interactions and co-prescribing with diltiazem or amlodipine
 May 2014: Statins: benefits and risks
September 2023: Statins: very infrequent reports of myasthenia gravis
NICE Guidance (also see drug-specific links below)
Summary of National Guidance for Lipid Management for Primary and Secondary Prevention of CVD
CG181: Cardiovascular disease, risk assessment and reduction, including lipid modification, July 2014 (updated September 2016)
CG71: Familial hypercholesterolaemia: identification and management, August 2008 (updated October 2019)
Local guidance
Colestyramine is an anion exchange resin and interferes with the absorption of other drugs. Other drugs should be taken at least 1 hour (ezetimibe 2 hours) before or 4-6 hours after taking colestyramine.
| Pack | Price |
|---|---|
| 28 tablet | £0.65 |
| 30 tablet |
| Pack | Price |
|---|---|
| 28 tablet | £0.69 |
| Pack | Price |
|---|---|
| 28 tablet | £0.80 |
| Pack | Price |
|---|---|
| 28 tablet | £1.40 |
| Pack | Price |
|---|---|
| 100 tablet | |
| 14 tablet | |
| 28 tablet | £0.73 |
| 30 tablet | |
| 84 tablet | |
| 90 tablet |
| Pack | Price |
|---|---|
| 10 tablet | |
| 14 tablet | |
| 28 tablet | £1.03 |
| 30 tablet | |
| 84 tablet | |
| 90 tablet |
| Pack | Price |
|---|---|
| 28 tablet | £0.95 |
| 30 tablet | |
| 90 tablet |
| Pack | Price |
|---|---|
| 28 tablet | £1.35 |
| 30 tablet | |
| 90 tablet |
| Pack | Price |
|---|---|
| 28 tablet | £1.51 |
| Pack | Price |
|---|---|
| 28 tablet | £1.65 |
| Pack | Price |
|---|---|
| 28 tablet | £1.88 |
| Pack | Price |
|---|---|
| 28 tablet | £0.78 |
| 30 tablet | |
| 90 tablet |
| Pack | Price |
|---|---|
| 28 tablet | £0.89 |
| 30 tablet | |
| 98 tablet |
| Pack | Price |
|---|---|
| 28 tablet | £1.29 |
| 30 tablet | |
| 98 tablet |
| Pack | Price |
|---|---|
| 28 tablet | £1.42 |
Ezetimibe is only indicated for the treatment of primary heterozygous (familial and non-familial) hypercholesterolaemia where statins are contraindicated or not tolerated. Ezetimibe may be co-adminstered with a statin where response has not been adequate or increased doses of statin have not been tolerated.
| Pack | Price |
|---|---|
| 28 tablet | £1.51 |
| 30 tablet |
Bempedoic acid is recommended only in combination with ezetimbe. They may be prescribed as separate tablets or as the fixed dose combination.
| Pack | Price |
|---|---|
| 28 tablet (2 x 14 tablets) | £55.44 |
Bempedoic acid is recommended only in combination with ezetimbe. They may be prescribed as separate tablets or as the fixed dose combination.
| Pack | Price |
|---|---|
| 28 tablet | £55.44 |
To be prescribed according to NICE TA 733 (see link above) and K&M ICB Position Statement (see here)
| Pack | Price |
|---|---|
| 1 pre-filled disposable injection | £1,987.36 |
To be prescribed according to NICE TA 805 (see link above).
| Pack | Price |
|---|---|
| 120 capsule | £144.21 |
| Pack | Price |
|---|---|
| 100 tablet | £8.63 |
| Pack | Price |
|---|---|
| 28 tablet | |
| 30 tablet | £7.63 |
| Pack | Price |
|---|---|
| 60 capsule | |
| 90 capsule | £23.23 |
| Pack | Price |
|---|---|
| 28 tablet | £3.06 |
| 30 tablet |
| Pack | Price |
|---|---|
| 28 capsule | £2.68 |
| 30 capsule |
| Pack | Price |
|---|---|
| 28 capsule | £3.22 |
| 30 capsule |
| Pack | Price |
|---|---|
| 1 pre-filled disposable injection | £168.00 |
| 2 pre-filled disposable injection | £336.00 |
| Pack | Price |
|---|---|
| 1 pre-filled disposable injection | £168.00 |
| 2 pre-filled disposable injection | £336.00 |
| Pack | Price |
|---|---|
| 1 pre-filled disposable injection |
| Pack | Price |
|---|---|
| 2 pre-filled disposable injection | £340.20 |