MTW NHS Trust West Kent CCG

Drug Status Key

  • Preferred
  • Second Line
  • Third Line
  • Specialist Initiation
  • Hospital Only
  • Not Approved for Formulary

Lipid regulating drugs

Drug Safety Update

  January 2008: Statin interactions and updated advice for atorvastatin

  February 2008: Statins - additional side effects including depression, sleep disturbance, memory loss, interstitial lung disease, and sexual dysfunction

 May 2010: Simvastatin increased risk of myopathy at high doses (80mg)

  December 2010: Fibrates first line treatment not recommended except for those with severe hypertriglyceridaemia

  January 2012: Statins risk of hyperglycaemia and diabetes

  August 2012: and  October 2012 Updated advice on simvastatin interactions and co-prescribing with diltiazem or amlodipine

 May 2014: Statins: benefits and risks

NICE Guidance (also see drug-specific links below)

 CG181: Cardiovascular disease, risk assessment and reduction, including lipid modification, updated Sept 2016

 NICE flowchart: Familial hypercholesterolaemia overview, updated July 2018 

Local guidance

Implementation Guidance for NICE TA 694: Bempedoic acid with ezetimibe for treating primary hypercholesterolemia or mixed dyslipedaemia

Colestyramine is an anion exchange resin and interferes with the absorption of other drugs. Other drugs should be taken at least 1 hour (ezetimibe 2 hours) before or 4-6 hours after taking colestyramine.

Pack Price
28 tablet £0.80
30 tablet
Pack Price
28 tablet £0.82
Pack Price
28 tablet £0.94
Pack Price
28 tablet £1.31
Pack Price
100 tablet
14 tablet
28 tablet £0.71
30 tablet
84 tablet
90 tablet
Pack Price
10 tablet
14 tablet
28 tablet £0.93
30 tablet
84 tablet
90 tablet
Pack Price
28 tablet £0.99
30 tablet
90 tablet
Pack Price
28 tablet £1.33
30 tablet
90 tablet
Pack Price
28 tablet £0.95
Pack Price
28 tablet £1.09
Pack Price
28 tablet £1.29
Pack Price
28 tablet £0.92
30 tablet
90 tablet
Pack Price
28 tablet £1.04
30 tablet
98 tablet
Pack Price
28 tablet £1.27
30 tablet
98 tablet
Pack Price
28 tablet £1.70

Ezetimibe is only indicated for the treatment of primary heterozygous (familial and non-familial) hypercholesterolaemia where statins are contraindicated or not tolerated. Ezetimibe may be co-adminstered with a statin where response has not been adequate or increased doses of statin have not been tolerated.

Pack Price
28 tablet £1.39
30 tablet

Bempedoic acid is recommended only in combination with ezetimbe. They may be prescribed as separate tablets or as the fixed dose combination.

Pack Price
28 tablet (2 x 14 tablets) £55.44

Bempedoic acid is recommended only in combination with ezetimbe. They may be prescribed as separate tablets or as the fixed dose combination.

Pack Price
28 tablet £55.44

To be prescribed according to NICE TA 733 (see link above).

Pack Price
1 pre-filled disposable injection £1,987.36
Pack Price
100 tablet £8.63
Pack Price
28 tablet
30 tablet £7.63
Pack Price
60 capsule
90 capsule £23.23
Pack Price
28 tablet £3.74
30 tablet
Pack Price
28 capsule £2.73
30 capsule
Pack Price
28 capsule £3.54
30 capsule
Pack Price
1 pre-filled disposable injection £168.00
2 pre-filled disposable injection £336.00
Pack Price
1 pre-filled disposable injection £168.00
2 pre-filled disposable injection £336.00