MTW NHS Trust West Kent CCG

Drug Status Key

  • Preferred
  • Second Line
  • Third Line
  • Specialist Initiation
  • Hospital Only
  • Not Approved for Formulary

Antiemetics and Antinauseants

Drug Safety Update

 August 2012: Ondansetron (Zofran) important new intravenous dose restrictions for high doses used in the management of chemotherapy induced nausea and vomiting

 August 2013: Ondansetron for intravenous use posology in patients aged 65 years and older - new advice on dilution and administration when being used for the management of chemotherapy induced nausea and vomiting

 August 2013: Metoclopramide - risk of neurological side effects

 May 2014: Domperidone - risk of cardiac side effects

 December 2019: Domperidone for nausea and vomiting: lack of efficacy in children; reminder of contraindications in adults and adolescents

 January 2020: Ondansetron: small increased risk of oral clefts following use in the first 12 weeks of pregnancy

First-line for PONV

Pack Price
10 tablet £2.00
30 tablet £2.13
Pack Price
10 tablet £1.66
Pack Price
10 tablet £43.46
Pack Price
10 tablet £85.43
Pack Price
50 ml £38.18
Pack Price
5 ampoule £29.97
Pack Price
5 ampoule £15.00

Useful for the treatment of vertigo

Pack Price
28 tablet (2 x 14 tablets) £0.59
84 tablet (6 x 14 tablets) £1.77

Buccastem can be purchased OTC for nausea & vomiting in previously diagnosed migraine

Pack Price
8 tablet £4.01
Pack Price
100 ml £3.34
Pack Price
10 ampoule £5.23

Effective in treating nausea and vomiting resulting from many underlying causes. Use second line for PONV.

Pack Price
100 tablet (10 x 10 tablets) £6.46
Pack Price
5 ampoule £16.25

Licensed for motion sickness also used off licence for hypersalivation

Releases 1mg hyoscine over 72hours

Pack Price
2 patch £12.87
Pack Price
100 tablet (10 x 10 tablets) £2.93
30 tablet (3 x 10 tablets) £0.88
Pack Price
200 ml £13.43

Used in palliative care

Pack Price
84 tablet (3 x 28 tablets) £20.26
Pack Price
10 ampoule £20.13

Used for nausea & vomiting associated with cancer chemotherapy or palliative care.

Dexamethasone injection is usually prescribed in terms of dexamethasone base - see IV guide for more details.

Pack Price
100 tablet £17.99
50 tablet £8.10
Pack Price
10 ampoule £22.08
Pack Price
10 vial £19.99